TY - JOUR AU - Rivera, Fabrizio AU - Comba, Luca AU - Perticarini, Loris AU - Benazzo, Francesco PY - 2021/04/27 Y2 - 2024/03/28 TI - When numbers don’t satisfy science: multicenter studies and digital protocols JF - Lo Scalpello - Journal JA - Lo Scalpello VL - 35 IS - 1 SE - Trauma Meeting DO - 10.36149/0390-5276-207 UR - https://www.loscalpellojournal.com/article/view/207 SP - 49-52 AB - Megaprostheses were introduced in oncological orthopedic surgery for reconstruction after bone tumor resections with good results; more recently, megaprostheses have been receiving an increasing role even in non-neoplastic hip and knee conditions like periprosthetic and very comminuted osteoporotic fractures and in treatment for resistant non-union of femur fractures. Nevertheless, literature about the use of megaprosthesis, especially in non-oncological musculoskeletal conditions, is still lacking high evidence level studies showing long-term outcomes. The purpose of this paper is carry out a review of the current megaprosthesis literature and present a multicenter study on a new prosthetic implant (“SMS multicentric study”), collecting the data on the use of a single implant (Smart Modularity System/SMS) in 11 orthopedic centers in order to obtain clinical and radiographic results. ER -